Substituted aromatic oligomers

摘要

The present invention relates to novel chemical compounds formula (I) (C)n—B-(A)m-B—(C)n (I) wherein m is 0 or 1, and n is independently 0, 1, 2 or 3, A, each B and each C are independently selected from phenylene and five- and six-membered heteroaromatic rings, and for a terminal ring B or C also from bicyclic heteroaromatic fused rings having seven to ten ring members, wherein the bond between at least two of the rings A to C may be replaced by a carbonyl group (—CO—), wherein at least two of the rings A to C are substituted with one or two groups R, and wherein each ring A to C further optionally is substituted with one or two groups R1. The compounds are useful in therapy, especially therapy of a mammal suffering from a disease involving misfolded or aggregated forms of proteins.

主权项

1. A compound of formula (II)or a pharmaceutically acceptable salt thereof, wherein
each o is independently 0, 1, or 2; each p is independently 0, 1, or 2; each u is independently 0, 1, or 2; each v is independently 0, 1, 2, or 3, with the proviso that the sum of o, p, u, and v is greater than 1; each R5, R6, and R7 are independently selected from carboxyalkyl, aminoalkyl, acylaminoalkyl, acyloxyalkyl, hydroxyalkyl, alkylsulphonyl, alkylsulphinyl, alkylaminosulphonyl, alkoxycarbonylalkyl, morpholinoalkyl, carboxyalkenyl, hydroxy, alkoxycarbonyl, pyrrolidinecarbonyl, morpholino, cycloalkylcarbamoyl, cyano, trifluoromethoxy, carbamoyl, hydroxyalkoxyalkyl, carbamoylalkyl, hydroxyalkylaminoalkyl, cyanoalkyl, alkylaminoalkyl, aminoalkylaminoalkyl, carboxyalkylaminoalkyl, piperidinealkyl, and piperazinealkyl; each R8 is independently selected from halo, alkyl, trifluoromethyl, carboxy, carboxyalkyl, aminoalkyl, acylaminoalkyl, acyloxyalkyl, hydroxyalkyl, alkylsulphonyl, alkylsulphinyl, alkylaminosulphonyl, alkoxycarbonylalkyl, morpholinoalkyl, carboxyalkenyl, hydroxy, alkoxycarbonyl, pyrrolidinecarbonyl, morpholino, cycloalkylcarbamoyl, cyano, trifluoromethoxy, carbamoyl, hydroxyalkoxyalkyl, carbamoylalkyl, hydroxyalkylaminoalkyl, cyanoalkyl, alkylaminoalkyl, aminoalkylaminoalkyl, carboxyalkylaminoalkyl, piperidinealkyl, and piperazinealkyl; and any alkyl moiety is C1-6-alkyl and any alkenyl moiety is C2-6-alkenyl, respectively.