Antiviral cationic polyamines were prepared by modifying polyethylenimines with N-acylating agents that introduce a side chain comprising one or more carbons and at least one alcohol hydroxy group. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant monosaccharide groups, which can be introduced via a cyclic carbonate comprising a pendant protected monosaccharide (e.g., mannose) group. The cationic polyamines can be active and selective against a broad spectrum of viruses at low concentrations, and are generally non-toxic.
申请公布号
SG10201600619W(A)
申请公布日期
2016.08.30
申请号
SG10201600619W
申请日期
2016.01.26
申请人
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH;INTERNATIONAL BUSINESS MACHINES CORPORATION;NATIONAL UNIVERSITY OF SINGAPORE
发明人
YANG, YI YAN;YAMAMOTO, NAOKI;YANG, CHUAN;KOJI, ICHIYAMA;HEDRICK, JAMES L.