Oncolytic adenoviruses for treating cancer

摘要

The invention relates to an oncolytic adenovirus that comprises a sequence that encodes a hyaluronidase enzyme inserted in the genome thereof. This adenovirus is distributed more efficiently through the mass of the tumour and consequently the oncolytic effect is enhanced. Endovenous injection of the oncolytic adenovirus of the invention gives rise to regressions in tumour volume. Therefore, the oncolytic adenovirus of the present invention can be used to treat cancer or a pre-malignant stage thereof.