发明名称 |
ANTIVIRALE THERAPIE GEGEN HEPATITIS B MIT 2',3'-DIDESOXYNUCLEOSIDEN. |
摘要 |
A method is disclosed for the treatment of hepadnavirus infection in animals. Animals infected with duck hepatitis B virus may be treated with the 2 min ,3 min -dideoxynucleoside of adenine, guanine, hypoxanthine, 2,6-diaminopurine or various analogs of substituted purines. Several purine 2 min ,3 min -dideoxynucleosides inhibit duck hepatitis B virus in hepatocyte culture >99% at 1 mu g/ml. Potent in vivo efficacy of the 2,6-diaminopurine 2 min ,3 min -dideoxynucleoside for clearance of duck hepatitis B virus from the sera of Pekin ducks is demonstrated. The selective effect on hepadnavirus replication by the purine 2 min ,3 min -dideoxynucleosides is based on the discovery of an unexpected sensitivity of hepadnavirus to purine 2 min ,3 min -dideoxynucleoside analogs. These compounds present a new antiviral therapy of acute or persistent hepadnavirus infections. |
申请公布号 |
DE3873207(D1) |
申请公布日期 |
1992.09.03 |
申请号 |
DE19883873207 |
申请日期 |
1988.08.08 |
申请人 |
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, EDMONTON, ALBERTA, CA |
发明人 |
TYRRELL, DAVID L.J., EDMONTON ALBERTA, T5R 5P6, CA;ROBINS, MORRIS J., PROVO UTAH 84604, US;SUZUKI, SATORU, HOKKAIDO 042, JP |
分类号 |
C07D473/16;A61K;A61K31/52;A61K31/522;A61K31/70;A61P31/12;C07D473/18;C07D473/24;C07D473/30;C07D473/32;C07D473/34;C07D473/40;(IPC1-7):A61K31/70 |
主分类号 |
C07D473/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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