VECTORS BASED ON RECOMBINANT DEFECTIVE VIRAL GENOMES, AND THEIR USE IN THE FORMULATION OF VACCINES

摘要

The vectors comprise a recombinant defective viral genome which expresses at least one antigen appropriate for inducing secretory and systemic immune responses or an antibody which provides protection against an infectious agent. The viral defective genome comprises the genome of a parental virus which has the signs of recognition of the viral replicase which are located at the extremities 3' and 5', and comprises additionally internal deletions, and wherein said defective viral genome depends on a complementing virus for its replication and encapsidation. Said vectors are appropriate to form a recombinant system which comprises said expression vector and a complementing virus. The system is appropriate for the preparation of mono- and polyvalent vaccines against infectious agents of various animal species, specially pigs, dogs and cats, and as vehicles for the expression of protection antibodies against infectious agents.