发明名称 |
Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates and uses thereof |
摘要 |
This invention provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention also provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclide of low to moderate cytotoxicity and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention further provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a heterotetramer comprising two heavy chains and two light chains, both heavy chains being either 1) IgG2 heavy chains or b) chimeric CD4-IgG2 heavy chains, and both light chains being either a) kappa light chains or b) chimeric CD4-kappa light chains. This invention further provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclide of low to moderate cytotoxicity and 2) a heterotetramer comprising two heavy chains and two light chains, both heavy chains being either a) IgG2 heavy chains or b) chimeric CD4-IgG2 heavy chains, and both light chains being either a) kappa light chains or b) chimeric CD4-kappa light chains. Finally, this invention provides methods of using the immunoconjugates of the subject invention.
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申请公布号 |
US6342586(B1) |
申请公布日期 |
2002.01.29 |
申请号 |
US19990409006 |
申请日期 |
1999.09.29 |
申请人 |
PROGENICS PHARMACEUTICALS, INC. |
发明人 |
ALLAWAY GRAHAM P.;MADDON PAUL J. |
分类号 |
C07K14/73;(IPC1-7):C07K16/00;A61K51/00;A61K39/395 |
主分类号 |
C07K14/73 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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