发明名称 |
MATERIALS AND METHODS |
摘要 |
The invention relates to methods of controlling orientation of direct covalent binding of a peptide to a polymer substrate surface, to surfaces with peptides directly covalently bound thereto in a manner where the orientation of binding is controlled as well as to devices comprising such substrates. In particular the invention relates to A method of controlling predominant orientation of direct covalent binding of one or more peptides to a polymer substrate surface comprising: (a) exposing the surface to energetic ion treatment to generate a plurality of activated sites comprising reactive radical species; (b) incubating the surface with one or more peptide/s that exhibit or can be induced to exhibit a dipole moment and manipulating the electric field environment and/or charge of said surface and/or of said peptide/s during said incubating; wherein predominant orientation of direct covalent binding of said peptide/s to said surface is thereby controlled. |
申请公布号 |
US2016215111(A1) |
申请公布日期 |
2016.07.28 |
申请号 |
US201414915933 |
申请日期 |
2014.09.02 |
申请人 |
THE UNIVERSITY OF SYDNEY |
发明人 |
Bilek Marcela;Kondyurin Aleksey;BAX Daniel Victor;Weiss Anthony Steven |
分类号 |
C08J7/12;A61L31/10;A61L31/16;A61L31/04 |
主分类号 |
C08J7/12 |
代理机构 |
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代理人 |
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主权项 |
1. A method of controlling predominant orientation of direct covalent binding of one or more peptides to a polymer substrate surface comprising:
(a) exposing the surface to energetic ion treatment to generate a plurality of activated sites comprising reactive radical species; (b) incubating the surface with one or more peptide/s that exhibit or can be induced to exhibit a dipole moment and manipulating the electric field environment and/or charge of said surface and/or of said peptide/s during said incubating;wherein predominant orientation of direct covalent binding of said peptide/s to said surface is thereby controlled. |
地址 |
Sydney, New South Wales AU |