| 发明名称 | Retinal derivatives and methods for the use thereof for the treatment of visual disorders | ||
| 摘要 | Compositions of and methods for using synthetic retinal derivatives as retinoid replacements and opsin agonists are provided. | ||
| 申请公布号 | US9403765(B2) | 申请公布日期 | 2016.08.02 |
| 申请号 | US201213619945 | 申请日期 | 2012.09.14 |
| 申请人 | University of Washington | 发明人 | Palczewski Krzysztof;Batten Matthew |
| 分类号 | A61K31/215;C07C403/14;C07C403/10;C07C403/12;C07C403/20;A61K31/22 | 主分类号 | A61K31/215 |
| 代理机构 | McDermott Will & Emery LLP | 代理人 | Mahoney Jacqueline F.;Mohr Judy M.;McDermott Will & Emery LLP |
| 主权项 | 1. A method of ameliorating or restoring photoreceptor function in a human eye, comprising: administering an effective amount of a synthetic retinyl ester that is a 9-cis-retinyl ester or an 11-cis-retinyl ester to a human subject with a deficiency in endogenous 11-cis-retinal in the eye, wherein the 9-cis-retinyl ester has a structure as represented by Formula I or the 11-cis-retinyl ester has a structure as represented by Formula II, wherein A in each formula is CH2OR and —R, along with the adjacent oxygen, forms a retinyl ester, and the ester substituent comprises a carboxylate radical of a C1 to C10 monocarboxylic acid or a C2 to C22 polycarboxylic acid: | ||
| 地址 | Seattle WA US | ||