发明名称 |
Method of identifying precursor ions |
摘要 |
A method of mass spectrometry is disclosed comprising mass selectively transmitting precursor ions from a mass analyzer into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce fragment or product ions; mass analyzing the fragment or product ions; determining the start and end times at which a first fragment or product ion is detected; using said start and end times to determine the start and end times at which a precursor ion of said first fragment or product ion is transmitted by said mass analyzer; and using the start and end times at which the precursor ion is transmitted by said mass analyzer to determine a mass to charge ratio of said precursor ion. The present invention enables precursor ion peaks to be resolved from the fragment data even when a low resolution mass analyzer is used to analyze the precursor ions. |
申请公布号 |
US9460902(B2) |
申请公布日期 |
2016.10.04 |
申请号 |
US201314401228 |
申请日期 |
2013.05.09 |
申请人 |
Micromass UK Limited |
发明人 |
Wildgoose Jason Lee |
分类号 |
H01J49/40;H01J49/00 |
主分类号 |
H01J49/40 |
代理机构 |
Diederiks & Whitelaw, PLC |
代理人 |
Diederiks & Whitelaw, PLC |
主权项 |
1. A method of mass spectrometry comprising:
mass selectively transmitting precursor ions from a mass analyser into a fragmentation or reaction device, wherein the mass to charge ratios of the ions transmitted varies with time; fragmenting the precursor ions in the fragmentation or reaction device so as to produce fragment or product ions; mass analysing and detecting the fragment or product ions; determining the start and end times at which a first fragment or product ion is detected; determining, based on said start and end times, the start and end times at which a precursor ion of said first fragment or product ion was transmitted by said mass analyser; and then determining, based on the start and end times at which the precursor ion was transmitted by said mass analyser, a mass to charge ratio of said entire precursor ion. |
地址 |
Wilmslow GB |