发明名称 GENE EXPRESSION PROFILE ALGORITHM AND TEST FOR LIKELIHOOD OF RECURRENCE OF COLORECTAL CANCER AND RESPONSE TO CHEMOTHERAPY
摘要 PROBLEM TO BE SOLVED: To provide information on the likelihood of recurrence of colorectal cancer in a patient and/or likelihood of beneficial response to chemotherapy comprising measurement of the expression levels of prognostic and/or predictive genes derived from a biological sample obtained from a cancer patient, and analysis of the measured expression levels.SOLUTION: Provided is a method for determining a likelihood of cancer recurrence after surgery in a patient with colorectal cancer, which comprises the steps of: measuring expression levels of prognostic genes in a tumor sample obtained from the patient; calculating a recurrence score (RS) for the patient using the measured gene expression levels, wherein the RS is calculated by assigning the measured expression levels to gene subsets of an RS algorithm, wherein the gene subsets comprise at least one gene each from a stromal group and a cell cycle group; and generating a report based on the RS.SELECTED DRAWING: Figure 1-1
申请公布号 JP2016104014(A) 申请公布日期 2016.06.09
申请号 JP20150247014 申请日期 2015.12.18
申请人 GENOMIC HEALTH INC 发明人 SHAK STEVEN;WATSON DREW;LI XITONG;LAWRENCE LEE;KIM LANGONE
分类号 C12Q1/68;C12N15/09;G01N33/68 主分类号 C12Q1/68
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