发明名称 |
Transport protein which is used to introduce chemical compounds into nerve cells |
摘要 |
The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells with a higher affinity as the native neurotoxin. The invention also relates to a method for the production of transport protein, the nucleic acids coding for the transport protein, the transport protein containing pharmaceutical and cosmetic compositions and use thereof. |
申请公布号 |
US9422344(B2) |
申请公布日期 |
2016.08.23 |
申请号 |
US201414451668 |
申请日期 |
2014.08.05 |
申请人 |
Ipsen Bioinnovation Limited |
发明人 |
Rummel Andreas |
分类号 |
C07K14/33;A61K47/48;A61K8/66;A61K38/48;A61Q19/08;A61K38/00 |
主分类号 |
C07K14/33 |
代理机构 |
McCarter & English, LLP |
代理人 |
McCarter & English, LLP ;Davis Steven G.;Lu Yu |
主权项 |
1. A transport protein, obtained by modification of the heavy chain of a Clostridium botulinum type A (BoNT/A), said heavy chain comprising a HN-fragment and a HC-fragment, wherein the HC fragment corresponding to amino acids 867-1296 of Clostridium botulinum neurotoxin type A (BoNT/A) protein sequence of SEQ ID NO: 1, 14, 15 or 16 is substituted by a HC fragment corresponding to amino acids 866-1291 of Clostridium botulinum neurotoxin type B (BoNT/B) protein sequence of SEQ ID NO: 17, 18, 19, 20, 21, or 22. |
地址 |
Abingdon, Oxfordshire GB |