DIAMINOPYRROLO QUINAZOLINES DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS

摘要

FIELD: chemistry, pharmaceutics. ^ SUBSTANCE: invention relates to novel derivatives of diaminopyrrolo quinazoline of formula (I), which possess properties of protein tyrosine phosphatase PTP-1B inhibitors and can be used for reduction of glucose concentration in blood. In general formula (I) A stands for 5- or 6-member unsaturated or saturated hydrocarbon ring or 5- or 6-member unsaturated or saturated ring, which contains at least one heteroatom, selected from S, N or O, R1 represents hydrogen or lower alkyl; Ra represents hydrogen, ^ , ^ , ^ , ^ or lower alkyl , R1, Ra, Rb, Rc, Rd, Re, Rf are such as defined in invention formula. ^ EFFECT: obtaining derivatives of diaminopyrrolo quinazoline which possess properties of protein tyrosine phosphatase inhibitors. ^ 32 cl, 5 dwg, 118 ex