2-ACYLAMINOTHIAZOLES FOR THE TREATMENT OF CANCER

摘要

The present invention relates to inhibitors of the oncogenic protein kinase ALK of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) are useful in the preparation of a medicament, in particular for the treatment of cancer.

主权项

1. The compounds of formula (I) wherein: —R1 is i equals zero, 1 or 2 Rx and Rx′ can be the same or different and are a C1-C3 linear or branched alkyl; X is either oxygen or NRy; Ry is a C1-C3 linear or branched alkyl or propargyl; Rz is either hydrogen or C1-C3 linear or branched alkyl; —R2 and —R3 can be the same or different and are hydrogen, linear or branched C1-C3 alkyl or —C≡C—R4, provided that at least one of —R2 and —R3 is —C≡C—R4; —R4 is hydrogen, —CH2—O—CPh3, cyclohexenyl, C1-C4 alkyl, Rt and Rt′ can be the same or different and are C1-C3 alkyl optionally substituted with one or more fluorine atoms, C1-C3 alkoxy optionally substituted with one or more fluorine atoms or F; Ra, Rb and Rc can be the same or different and can be phenyl or C1-C4 linear or branched alkyl; and pharmaceutically acceptable salts thereof.