发明名称 |
USE OF GLUCOSIDASE INHIBITORS FOR THERAPY OF MUCOVISIDOSIS |
摘要 |
<p>Glucosidase inhibitors are used to prepare medicaments for treating mucoviscidosis. - ACTIVITY - CNS-Gen.; Respiratory-Gen. - MECHANISM OF ACTION - Reactivator of cystic fibrosis transmembrane conductance regulator (CFTR) protein delF508 mutant. - N-butyl deoxynojirimycin had an EC50 of 123 mu M for restoring iodide efflux in CF15 human lung epithelial cells (which are homozygotic for the delF508 mutation) after stimulation with forskoline and genisteine.</p> |
申请公布号 |
IL175453(D0) |
申请公布日期 |
2008.03.20 |
申请号 |
IL20060175453 |
申请日期 |
2006.05.04 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S);UNIVERSITE DE POITIERS |
发明人 |
|
分类号 |
A61K31/352;A61K31/437;A61K31/4375;A61K31/445;C07D |
主分类号 |
A61K31/352 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|