MUTANT cDNA ENCODING THE p85-g(a) SUBUNIT OF PHOSPHATIDYLINOSITOL 3-KINASE

摘要

A nucleic acid sequence comprising a DNA sequence encoding a regulatory subunit of phosphaditylinositol 3-kinase (P13K), the DNA sequence containing a mutation of at least one nucleotide, or comprising a segment of the DNA sequence including said mutation for use as a diagnostic tool, a marker or a probe. Examples of mutations in p85 alpha subunit are: C to T in nucleotide 261; T to G in nucleotide 663; A to G in nucleotide 810; G to A in nucleotide 1020.