发明名称 |
ELIMINATION OF FALSE NEGATIVES IN NUCLEIC ACID DETECTION |
摘要 |
The present invention relates to a method for the elimination of false negative test results in assays for the detection of amplified analyte nucleic acid in a sample. Prior to amplification, an internal control is added to the sample, comprising a nucleic acid distinguishable from the analyte nucleic acid, that can be amplified with the same amplification reagents as the analyte nucleic acid. Preferably the internal control comprises a nucleic acid sequence corresponding to the analyte nucleic acid that has been mutated to discriminate it from the analyte nucleic acid. |
申请公布号 |
WO9404706(A1) |
申请公布日期 |
1994.03.03 |
申请号 |
WO1993EP02248 |
申请日期 |
1993.08.20 |
申请人 |
AKZO N.V. |
发明人 |
KIEVITS, TIM;LENS, PETER, FRANKLIN |
分类号 |
C12N15/09;C12Q1/68;C12Q1/70;(IPC1-7):C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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