PROCESS OF PREPARING 1,2,2,2-TETRAFLUOROETHYL-DIFLUOROMETHYL ETHER

摘要

CF3CHFOCHF2 useful as an anaesthetic is formed by fluorinating CF3CHXOCHF2, wherein X is a halogen atom other than fluorine atom, by an alkali metal fluoride in an aprotic polar solvent in the presence of a phase-transfer catalyst such as tetramethylammonium chloride or 18-crown-6-ether. The reaction proceeds under mild conditions, and the selectivity to the aimed compound is very high. The aimed compound can easily be separated from unreacted starting compound since the boiling point of the starting compound sufficiently differs from that of the aimed compound.