Pyrimidine Compounds for the Treatment of Hepatitis C

摘要

The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.;

主权项

1. A compound of formula I where X and Y are N and Z is CH, Y and Z are N and X is CH; or X and Z are N and Y is CH; R1 is alkyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, cycloalkyl, hydroxycycloalkyl, alkoxycycloalkyl, halocycloalkyl, cycloalkenyl, indanyl, alkylcarbonyl, or benzyl wherein the benzyl moiety is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; R2 is alkyl, (Ar2)alkyl, (Ar2)cycloalkyl, ((Ar2)cycloalkyl)alkyl, ((Ar2)alkyl)cycloalkyl, or (((Ar2)alkyl)cycloalkyl)alkyl; R3 is hydrogen or alkyl; R4 is hydrogen or alkyl; R5 is  where ring A is a 4 to 7 membered alkylene ring substituted with L; R6 is hydrogen or alkyl; R2 is (Ar2)alkyl; R3 is hydrogen; R4 is hydrogen; R5 is R6 is hydrogen or alkyl; R7 is hydrogen, alkyl, cycloalkyl, or Ar3; R8 is hydrogen or alkyl; or R7 and R8 taken together with the nitrogen to which they are attached is piperidinyl, morpholinyl, or tetrahydroisoquinolinyl; L is alkylene; Ar1 is pyridinyl substituted with 1 CON(R5)(R6); Ar2 is phenyl substituted with 0-3 halo substituents; and Ar3 is phenyl, isoxazolyl, thiazolyl, or thiadiazolyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy; or a pharmaceutically acceptable salt thereof.