| 摘要 |
PURPOSE:To prepare a calcitonin gene-related peptide (CGRP) compound aqueous solution composition containing the CGRP compounds under specific conditions as an active ingredient and useful as a medicinal treatment injection excellent in heat and light stability. CONSTITUTION:The preparation of the CGRP compound aqueous solution compositions is to adjust the PH of a solution to 4-5 and the ion strength muof the solution 0.01-0.5m, respectively, with a buffer solution containing a monocarboxylic acid such acetic acid or lactic acid and/or its water-soluble salt in a molar concentration of 0.1-200mM and dissolve the CGRP compounds in a concentration of 0.001-5000mug per ml of the solution as an active ingredient. The aqueous solution composition is stable against heat and light, even when stored for a month at 40 deg.C, and the give stable infusion solution compositions within a dripping period. |
