Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha

摘要

Compounds of formula (I) and solvates thereof; processes for preparing them and their use in therapy are disclosed, wherein R1 represents C1-6 alkyl or C1-6 haloalkyl; R2 represents C3-8 cycloalkyl or C3-8 cycloalkenyl either of which may optionally be substituted by one or more groups selected from oxo, methyl, methylene and halogen; R3 represents hydrogen, methyl (which may be in either the alpha or beta configuration) or methylene; R4 and R5 are the same or different and each represents hydrogen or halogen; and the dotted line ----- represents a single or a double bond.