发明名称 |
CATIONIC AMPHIPHILE MICELLAR COMPLEXES |
摘要 |
The effective introduction of foreign genes and other biologically active molecules into targeted mammalian cells is a challenge still facing those skilled in the art. Gene therapy, for example, requires successful transfection of target cells in a patient. The present invention relates to novel micellar complexes of cationic amphiphilic compounds that facilitate delivery of biologically active molecules to the targeted cells of a mammal. The novel micellar complexes are comprised of a cationic amphiphile, a biologically active molecule, a derivative of polyethylene glycol (PEG), and optionally, a co-lipid. A further aspect of the invention is the use of targeting absents in any of the methods that effectuate the delivery of biologically active molecules into the cells of mammals. A targeting agent is usually any molecule, peptide sequence, or large protein that preferentially targets or binds to specific mammalian cells. |
申请公布号 |
WO9965461(A3) |
申请公布日期 |
2000.02.24 |
申请号 |
WO1999US13875 |
申请日期 |
1999.06.18 |
申请人 |
GENZYME CORPORATION |
发明人 |
TOUSIGNANT, JENNIFER, D.;EASTMAN, SIMON, J.;CHU, QUIMING;LEE, EDWARD, R.;FANG, SHAONA, L. |
分类号 |
C12N15/00;A61K9/00;A61K9/127;A61K31/711;A61K39/395;A61K47/24;A61K47/34;A61K47/42;A61K47/44;A61K47/48;A61K48/00 |
主分类号 |
C12N15/00 |
代理机构 |
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地址 |
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