发明名称 |
Gold(I) complexes with t-butyl phosphine and dialkyl dithiocarbamate ligands |
摘要 |
Gold(I) complexes of formulae [Au{P(t-Bu)3}(S2CN(CH3)2)] (1), and [Au{P(t-Bu)3}(S2CN(C2H5)2)] (2) have been prepared by the reaction of equimolar amounts of [Au{P(t-Bu)3}(Cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. These gold(I) dithiocarbamate complexes show in vitro cytotoxic activities against A549 (human lung carcinoma), HeLa (human cervical cancer) and MCF7 (human breast cancer) cell lines. |
申请公布号 |
US9492465(B2) |
申请公布日期 |
2016.11.15 |
申请号 |
US201615042852 |
申请日期 |
2016.02.12 |
申请人 |
King Fahd University of Petroleum and Minerals;King Abdulaziz City for Science and Technology |
发明人 |
Isab Anvarhusein Abdulkadir;Altaf Muhammad;Monim-Ul-Mehboob Muhammad;Seliman Adam Ahmed Abdallah;Wazeer Mohammed Ismail |
分类号 |
A61K31/66;C07F9/50;G01N33/50 |
主分类号 |
A61K31/66 |
代理机构 |
Oblon, McClelland, Maier & Neustadt, L.L.P. |
代理人 |
Oblon, McClelland, Maier & Neustadt, L.L.P. |
主权项 |
1. A method for treating cancer or a tumor comprising
administering, in a cytotoxically effective amount, a gold complex of formula Au{P(t-Bu)3}(S2CN(R)2) where R is CH3 or C2H5 to a subject in need of treatment for a human cervical cancer. |
地址 |
Dhahran SA |