Heart valve sealing devices

摘要

This disclosure pertains generally to prosthetic devices and related methods for helping to seal native heart valves and prevent or reduce regurgitation therethrough, as well as devices and related methods for implanting such prosthetic devices. In some cases, a spacer having a single anchor can be implanted within a native heart valve. In some cases, a spacer having dual anchors can be implanted within a native heart valve. In some cases, devices can be used to extend the effective length of a native heart valve leaflet.

主权项

1. A method of implanting a prosthetic sealing device at a native mitral valve of a heart, the method comprising:
advancing a delivery system to a native mitral valve region of a heart, the delivery system housing the prosthetic sealing device in a radially compressed configuration, the prosthetic sealing device comprising a main body and anchors extending from the main body, the main body comprising a radially expandable and compressible annular metal frame having an upstream end, a downstream end, and a lumen extending from the upstream end to the downstream end, the main body further comprising a blood impermeable fabric covering the frame; proximally retracting an outer sheath of the delivery system such that the anchors of the prosthetic sealing device are not confined within the delivery system; positioning the delivery system such that native mitral valve leaflets are positioned between the anchors of the prosthetic sealing device and the delivery system; proximally retracting an inner sheath of the delivery system such that the main body of the prosthetic sealing device is not confined within the delivery system and expands from the radially compressed configuration to a radially expanded configuration and is held between the native mitral valve leaflets by the anchors, which clamp portions of the native leaflets against the main body, wherein the fabric prevents blood from flowing through the lumen of the metal frame during systole and during diastole, wherein non-clamped portions of the native mitral valve leaflets can move away from the main body of the prosthetic device during diastole to allow blood from the left atrium to flow past the prosthetic device into the left ventricle, and the non-clamped portions of the native mitral valve leaflets can seal against the main body of the prosthetic device during systole to minimize mitral regurgitation; and removing the delivery system from the native mitral valve region of the heart; wherein an upstream end of the prosthetic sealing device is located downstream of the native mitral valve annulus when implanted.