METHODS OF IDENTIFYING SUBJECTS RESPONSIVE TO TREATMENT FOR AN AUTOIMMUNE DISEASE AND COMPOSITIONS FOR TREATING THE SAME

摘要

Methods of identifying a subject having an autoimmune disease, such as Type 1 diabetes, as likely to respond to treatment with a tumor necrosis factor-alpha (TNF-α) receptor II activator, involving measuring CD8 protein density on the surface of autoreactive CD8+ T cells and identifying the subject as likely to respond to the treatment if the CD8 protein density is reduced relative to a reference CD8+ T cell. For Type 1 diabetes, the method may involve measuring C-peptide levels in an in vitro biological sample from the subject, identifying the subject as likely to respond to the treatment if the C-peptide levels are detectable, and identifying the subject as unlikely to respond to the treatment if the C-peptide levels are substantially undetectable. The invention also features pharmaceutical compositions of one or more TNFR2 activators for therapeutic use.

主权项

1. A method of determining the likelihood a subject having an autoimmune disease will respond to treatment with a tumor necrosis factor-α (TNF-α) receptor II (TNFR2) activator comprising:
(i) contacting an in vitro biological sample comprising a population of CD8+ T cells from said subject with a composition comprising a TNFR2 activator; and (ii) measuring CD8 protein density on the surface of autoreactive CD8+ T cells in said population;wherein reduced CD8 protein density on the surface of said autoreactive CD8+ T cells relative to a reference CD8+ T cell indicates said subject is likely to respond to said treatment.