发明名称 HDAC INHIBITORS
摘要 This invention provides the compound having the structure wherein n is 1- 10; X is C-R11 or N, wherein R11 is H, OH, SH, F, Cl, SO2R7, NO2, trifluoromethyl, methoxy, or CO-R7, wherein R7 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl; R2 is H or NR3R4, wherein R3 and R4 are each independently H, C1-C6 alkyl, or C3-C8 cycloalkyl; R5 is OH or SH; and R6, R12A R13, and R14are each independently H, OH, SH, F, Cl, SO2R15, NO2, trifluoromethyl, methoxy, or CO-R15, wherein R15 is alkyl, alkenyl, alkynyl, C3-C8 cycloalkyl, or aryl, or a salt of the compound, which is useful in the treatment of tumors.
申请公布号 CA2700857(C) 申请公布日期 2016.08.02
申请号 CA20082700857 申请日期 2008.10.01
申请人 LIXTE BIOTECHNOLOGY, INC. 发明人 KOVACH, JOHN S.;JOHNSON, FRANCIS
分类号 C07C323/62;A01N37/40;A01N37/46;A01N43/40;A01P3/00;A61K31/166;A61K31/4406;A61K31/455;A61P31/18;A61P35/00;C07C231/02;C07C235/60;C07D213/75;C07D213/82 主分类号 C07C323/62
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