| 发明名称 |
FGF modulation of in vivo antibody production and humoral immunity |
| 摘要 |
The invention provides methods for increasing or decreasing antibody production in vivo by inhibiting or promoting the activity of fibroblast growth factor-2 (FGF2) respectively. |
| 申请公布号 |
US9359433(B2) |
申请公布日期 |
2016.06.07 |
| 申请号 |
US201514938235 |
申请日期 |
2015.11.11 |
| 申请人 |
Bush Andrew B. |
发明人 |
Bush Andrew B. |
| 分类号 |
A61K39/395;A61K39/39;C07K16/22;A61K45/00;C07K14/50;C07K16/00;A61K39/00 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for increasing humoral immune response to vaccination with an immunogen in a mammal, comprising: in conjunction with the vaccination of a mammal to an immunogen which is other than FGF2 and other than a fibroblast growth factor receptor, inhibiting the activity of FGF2 in the mammal by administering an antibody or fragment thereof that binds FGF2 to the mammal, thereby increasing the humoral immune response to the immunogen. |
| 地址 |
Princeton NJ US |
