| 发明名称 | Compounds and methods for kinase modulation, and indications therefor | ||
| 摘要 | Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. | ||
| 申请公布号 | US9469640(B2) | 申请公布日期 | 2016.10.18 |
| 申请号 | US201615048851 | 申请日期 | 2016.02.19 |
| 申请人 | Plexxikon Inc. | 发明人 | Wu Guoxian;Zhang Jiazhong;Zhu Yong-Liang;Zhang Chao;Ibrahim Prabha N.;Shi Songyuan;Spevak Wayne;Artis Dean R.;Tsai James |
| 分类号 | C07D213/72;C07D285/12;C07D261/04;C07D231/00;A61K31/44;A61K31/41;A61K31/42;A61K31/415;C07D471/04;C07D213/75;C07D213/82;C07D215/12;C07D215/20;C07D215/38;C07D239/48;C07D263/48;C07D417/12;A61K31/437;A61K31/444;A61K31/47;A61K31/5377;A61K31/549;A61K45/06;C07D215/14;C07D261/14;C07D285/16;A61K31/4439;A61K31/505;C07D213/76;C07D239/49;A61K31/506;C07D417/04;C07D213/74;C07D231/40;C07D285/135;C07D401/12;C07D405/12;C07D409/12 | 主分类号 | C07D213/72 |
| 代理机构 | Sheppard Mullin Richter & Hampton LLP | 代理人 | Sheppard Mullin Richter & Hampton LLP |
| 主权项 | 1. A compound of formula (Ia): or a pharmaceutically acceptable salt thereof, wherein: L1 is a bond or —N(H)C(O)—; each R1 is optionally substituted lower alkyl or optionally substituted heteroaryl; R2 is hydrogen or halogen; R4 is hydrogen; R3 is optionally substituted lower alkyl or optionally substituted aryl; m is 0, 1, 2, 3, 4, or 5; and Ar is a monocyclic heteroaryl containing 5 to 6 atoms wherein at least one atom is nitrogen. | ||
| 地址 | Berkeley CA US | ||