Organic compounds

摘要

The invention relates to compounds and methods of treatment relating to nicotinic receptor antagonists. For example, the compounds and methods of treatment function block the activity of certain acetylcholine receptors and subtypes therein, and are useful treating diseases and conditions mediated by nicotinic receptor stimulation, e.g., small cell lung cancer.

主权项

1. A compound of Formula I: wherein R1 is halogen, —SO2NH2, or —COOH; R2 is halogen, —SO2NH2, or —COOH, or H; Y and Z are independently a bond or —CH2—; X is N or CR6; R3 and R6 are independently H, phenyl, tolyl, ethyl or propyl; R5 is independently H, phenyl, tolyl, or lower alkyl; R4 is lower alkyl, or R4 is not present; in free or pharmaceutically acceptable salt form; provided that when R4 is lower alkyl, the compound forms a quaternary ammonium salt and there is an associated pharmaceutically acceptable anion present.