发明名称 |
Micro-RNA scaffolds, non-naturally occurring micro-RNAs, and methods for optimizing non-naturally occurring micro-RNAs |
摘要 |
<p>The present disclosure provides non-naturally occurring miR-196a-2 miRNAs and non-naturally occurring miR-204 miRNAs. The non-naturally occurring miRNAs of the disclosure have mature strand sequences distinct from their endogenous counterparts. The disclosure also provides methods of selecting mature strand sequences that function optimally in non-naturally occurring miR-196a-2 miRNAs. The methods and compositions of the disclosure may be used to mediate gene silencing via the RNAi pathway.</p> |
申请公布号 |
EP2155911(A1) |
申请公布日期 |
2010.02.24 |
申请号 |
EP20080780685 |
申请日期 |
2008.05.22 |
申请人 |
DHARMACON, INC. |
发明人 |
KELLEY, MELISSA;BIRMINGHAM, AMANDA;KARPILOW, JON;KHVOROVA, ANASTASIA;SULLIVAN, KEVIN |
分类号 |
C12N15/11;C12Q1/68 |
主分类号 |
C12N15/11 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|