| 主权项 |
1. A method of treating a disorder selected from the group consisting of an immune disorder and inflammatory disorder comprising administering to a human patient in need thereof a therapeutically effective amount of a compound of Formula I in order to ameliorate a symptom of the disorder, wherein Formula I is represented by: including all stereoisomers, geometric isomers, and tautomers; or a pharmaceutically acceptable salt or solvate of any of the foregoing; wherein: A1 is phenylene or a six-membered heteroarylene; A2 is X is —OP(O)(OR11)2; R1 represents independently for each occurrence halogen, alkyl, haloalkyl, hydroxyl, C1-C6alkoxy, or cyano; R2 is hydrogen; R3 is aryl, aralkyl, cycloalkyl, —(C(R6)2)m-cycloalkyl, heteroaryl, heteroaralkyl, or heterocycloalkyl, wherein said aryl, aralkyl, cycloalkyl, heteroaryl, heteroaralkyl, and heterocycloalkyl are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, haloalkyl, hydroxyl, alkyl, cycloalkyl, C1-C6alkoxy, and cyano; R4 is hydrogen; R5 is hydrogen, halogen, alkyl, alkoxyl, or —C(O)R7; R6 represents independently for each occurrence hydrogen, alkyl, or cycloalkyl; R7 represents independently for each occurrence alkyl or cycloalkyl; R8 is hydrogen or alkyl; R9 is alkyl, cycloalkyl, haloalkyl, —(C(R6)2)m-cycloalkyl, —C(R6)2)m—CN, aryl, aralkyl heteroaryl, or heteroaralkyl; R10 is alkyl, cycloalkyl, —(C(R6)2)m-cycloalkyl, haloalkyl, or C1-C6alkoxy; R11 represents independently for each occurrence hydrogen or an alkali metal; n is 1 or 2; and m is 1, 2, 3, 4, or 5. |
