METHODS OF ENHANCING DRUG DELIVERY AND EFFECTIVENESS OF THERAPEUTIC AGENTS

摘要

PROBLEM TO BE SOLVED: To provide methods for enhancing drug delivery and effectiveness of therapeutic agents.SOLUTION: The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water-soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water-soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the drug uptake capability as a result of the co-administration of the taxane nanoparticle composition in the target tissue. Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein.SELECTED DRAWING: None