METHOD FOR CRYSTALLIZING ALPHA-L-ASPARTYL-LPHENYLALANINE METHYL ESTER

摘要

PURPOSE:To crystallize a crystal of the subject compound having good filtrating property and dehydrating property by continuously feeding a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which the compound is dissolved. CONSTITUTION:Whenalpha-L-aspartyl-L-phenylalanine methyl ester (A2PM) is crystallized from a hot water solution containing alpha-L-aspartyl-L-phenylalanine methyl ester by cooling, the crystallization of A2PM is carried out by continuously feeding a hot water solution in which the content of L-aspartyl-Laspartyl-L- phenylalanine methyl ester (A2PM) is 0.6% smaller than the of alpha-L-spartyl-L- phenylalanine methyl ester to a crystallizing tank cooled to a temperature or below at which alpha-L-aspartyl-L-phenylalanine methyl ester is dissolved and simultaneously continuously drawing out the produced slurry from the crystallizing tank.