GENE BASED ASSAY FOR AGENTS WITH POTENTIAL THERAPEUTIC EFFICACY IN THE TREATMENT OF OBSESSIVE COMPULSIVE DISORDER AND DISORDERS RELATED THERETO

摘要

Methods of identifying subjects having a susceptibility to obsessive-compulsive disorder, and disorders related thereto, resulting from a reduced level of Cathechol-O-methyltransferase (COMT), or modulated levels of monoamine oxidase A are described. In addition, knockout mice expressing decreased levels of COMT relative to a wild type mouse are disclosed and characterized herein, along with methods for selecting therapeutic agents for possible use in the treatment of OCD or disorder related thereto.