| 发明名称 | Polyethylene glycol based oligomers for coating nanoparticles, nanoparticles coated therewith, and related methods | ||
| 摘要 | In a composition aspect of the invention, a nanoparticle coating comprises repeating polyacrylic acid monomers covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom. A first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal sulfur moiety. | ||
| 申请公布号 | US9446152(B2) | 申请公布日期 | 2016.09.20 |
| 申请号 | US201514838586 | 申请日期 | 2015.08.28 |
| 申请人 | The Florida State University Research Foundation, Inc. | 发明人 | Mattoussi Hedi;Palui Goutam;Na Hyon Bin |
| 分类号 | A61K49/00;H01F1/00;C08F8/32;C08F20/06;C08F22/00;C08K5/00;C08K5/13;C08L33/00;C08L71/08;C09D133/14;C08F220/26 | 主分类号 | A61K49/00 |
| 代理机构 | Armstrong Teasdale LLP | 代理人 | Armstrong Teasdale LLP |
| 主权项 | 1. A composition comprising: nanoparticles surface-capped with a coating composition, the coating composition comprising: repeating polyacrylic acid monomer units covalently bound together in an aliphatic chain having a plurality of carboxylic acid functional groups and modified carboxylic acid functional groups extending therefrom, wherein a first portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having a terminal methoxy functional group and a second portion of the modified carboxylic acid functional groups are modified by a PEG oligomer having at least one terminal sulfur moiety. | ||
| 地址 | Tallahassee FL US | ||