发明名称 Macrolides with antitumor activity
摘要 The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose, can its elf be derivatized or the sugar can be replaced, in either case, giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar.
申请公布号 US6395711(B1) 申请公布日期 2002.05.28
申请号 US20000485219 申请日期 2000.04.17
申请人 INSTITUTO BIOMAR S.A. 发明人 FERNANDEZ-CHIMENO ROSA ISABEL;ROMERO FRANCISCO;FERNANDEZ-PUENTES JOSE LUIS;PEREZ-BAZ JULIA;CANEDO LIBRADA MARIA;ESPLIEGO FERNANDO
分类号 A61K31/365;A61P35/00;C07D493/20;C12N1/20;C12P17/18;C12R1/29;(IPC1-7):A61K31/70;C07H17/08;C12P19/62;C12N1/00 主分类号 A61K31/365
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