Derivatives of sulindac, use thereof and preparation thereof

摘要

Derivatives of sulindac that lack cyclooxygenase inhibitory activity are provided along with pharmaceutical compositions containing them and use for treatment or prevention of cancer. The derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the derivatives is also provided.

主权项

1. A compound represented by the formula: wherein each of R4 and R5 is selected from the group consisting of H, alkyl, a substituted or unsubstituted 5 or 6 member ring and when substituted the 5 or 6 member ring is substituted with at least one member selected from the group consisting of alkyl, halo, alkoxy, amino and aminoalkyl, provided that at least one of R4 and R5 is a substituted or unsubstituted 5 or 6 member ring other than H; and when both R4 and R5 are a substituted or unsubstituted 5 or 6 member ring, both of R4 and R5 are a substituted or unsubstituted pyridyl ring; R6 is a substituted or unsubstituted 5 or 6 member ring; X is a halogen; and pharmaceutically acceptable salts thereof, solvates thereof and mixtures thereof.