| 摘要 |
Abstract Provided herein is a method for identifying a genetic variant that is associated with development of a condition 5 of interest (e.g., Alzheimer's disease), and genetic variants so identified. Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, 10 the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene. Kits for determining if a subject is at increased risk of developing late onset Alzehimer's disease is also provided. Kits for determining if a subject is responsive to treatment for a 15 condition of interest with an active agent are further provided. 74920041 (GHMatters) P86306.AU.2 PETERB 4/03/16 OBTAIN DNA SEQUENCE INFORMATION OF A DEFINED GENETIC LOCUS FROM AN APPROPRIATE SUBJECT POPULATION USE MULTIPLE SEQUENCE ALIGNMENT ALGORITHM TO DEFINE HAPLOTYPE BLOCKS IN THE GENETIC REGION BEING STUDIED CONSTRUCT PHYLOGENETIC TREE REPRESENTING LINKS BETWEEN DEFINED HAPLOTYPE BLOCKS TRAVEL DOWN BRANCHES OF THE PHYLOGENETIC TREE, COUNTING SUBJECTS REPRESENTING EACH OF A PHENOTYPE OF INTEREST FOR EACH NODE IDENTIFY A NODE WHERE THE RATIO OF AFFECTED:NONAFFECTED SUBJECTS FOR THE PHENOTYPE OF INTEREST IS SUBSTANTIALLY DIFFERENT THAN THAT OF THE PREVIOUS NODE, WHICH IS A BRANCHING POINT OF INTEREST |
