Method for bone marrow preservation or recovery

摘要

Methods for enhancing or stimulating hematopoiesis including the step of administering Interleukin-12 (IL-12) to yield hematopoietic recovery in a mammal in need. Preferred methods include the step of administering IL-12 as an adjuvant therapy to alleviate the hematopoietic toxicities associated with one or more treatment regimens used to combat a disease state. Other methods include administering IL-12 to ameliorate various hematopoietic deficiencies. Still other methods are directed to uses of IL-12 for in-vivo proliferation of hematopoietic repopulating cells, hematopoietic progenitor cells and hematopoietic stem cells. Other disclosed methods are directed to uses of IL-12 for bone marrow preservation or recovery.

主权项

1. A method for bone marrow preservation or recovery in a mammal having a hematopoietic malignancy comprising:
(a) administering a treatment to a mammal having a hematopoietic malignancy, wherein the mammal does not have a solid tumor and the treatment results in the near destruction of bone marrow in the mammal; and (b) administering a single therapeutically effective dose of IL-12 to the mammal, without the use of hematopoietic repopulating cells, hematopoietic progenitor cells or hematopoietic stem cells, wherein administration of the single therapeutically effective dose of IL-12 results in bone marrow preservation or recovery, wherein step (b) is performed before, during or after step (a); and wherein the dose of IL-12 is less than 500 ng/kg.