OLIGONUCLEOTIDES WHICH INHIBIT THE EXPRESSION OF THE OB-RGRP PROTEIN AND METHOD FOR DETECTION OF COMPOUNDS MODIFYING THE INTERACTION BETWEEN THE PROTEINS OF THE OB-RGRP FAMILY AND THE LEPTIN RECEPTOR

摘要

The invention relates to oligonucleotides which inhibit the expression of the OB-RGRP protein and use thereof for the prevention and/or treatment of diseases related to leptin. The invention further relates to a method for detection of compounds modifying the interaction between the proteins of the OB-RGRP family and the leptin receptor. Said detection can be achieved by means of the energy transfer between the fusion proteins comprising said proteins and proteins which are donors and acceptors of energy.