COMPUESTOS DERIVADOS DE MORFINA, ANTAGONISTAS DEL RECEPTOR OPIOIDE PERIFERICO; METODO DE PREPARACION; COMPOSICION FARMACEUTICA; Y USO PARA REDUCIR LOS EFECTOS DE LA ACTIVIDAD OPIOIDE ENDOGENA.

摘要

The present invention provides a compound of formula I: wherein R1, R2, R2′and X−are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.