发明名称 |
PROCESS FOR THE PREPARATION OF A QUINOLINE CARBOXYLIC ACID |
摘要 |
The invention provides a process for the preparation of a carboxylic acid of formula (IV) (which is useful as a safener for herbicides): wherein R1 is hydrogen or chlorine, comprising the steps of: (i) subjecting a compound of formula (V) wherein: R1 is as defined above; and R2 is C1-C18 alkyl; C1-C6 alkoxyC1-C8 alkyl-; optionally substituted phenyl; or optionally substituted benzyl; to hydrolysis under acidic conditions to give a solution of a quinolinium salt; and (ii) adding base to the solution obtained in step (i) to give the free carboxylic acid (IV). The invention also provides a solid (e.g. particulate) form of one quinoline carboxylic acid compound within formula (IV) defined by R1 being chlorine; and novel intermediates useable in the above process. |
申请公布号 |
EP2780323(A1) |
申请公布日期 |
2014.09.24 |
申请号 |
EP20120784277 |
申请日期 |
2012.11.14 |
申请人 |
SYNGENTA PARTICIPATIONS AG |
发明人 |
GOLLUT, JEAN-JACQUES ROGER;GAYET, ARNAUD JEAN ALBERT |
分类号 |
C07D215/04;A01N25/32;C07D215/10 |
主分类号 |
C07D215/04 |
代理机构 |
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