Analogs of temporin-SHa and uses thereof

摘要

The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions comprising said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pesticides or preservatives. The present invention also relates to a transgenic plant expressing said novel peptides.

主权项

1. A non-natural peptide of between 13 and 100 amino acids selected from the group consisting of:
a) a peptide containing the sequence F-L-X1-G-I-V-G-M-L-G-K-L-F (SEQ ID NO: 2) or a pharmaceutically acceptable salt thereof; b) a retropeptide or retro-inverso peptide of a peptide containing the sequence F-L-X1-G-I-V-G-M-L-G-K-L-F (SEQ ID NO: 2) or a pharmaceutically acceptable salt thereof; and c) a peptide containing the sequence of SEQ ID NO: 2 shortened by 1 or 2 amino acids at the N-terminal end or a pharmaceutically acceptable salt thereof; wherein said non-natural peptide or said pharmaceutically acceptable salt thereof as shown in group a), b) and c) exhibits antimicrobial activity and wherein X1 is an amino acid selected from the group consisting of R (arginine), H (histidine) and K (lysine).