TACHYKININ ANTAGONISTS

摘要

Compounds of formula (I), wherein Q<1> represents an aryl group; the dotted line represents an optional covalent bond; one of X and Y represents H and the other represents hydroxy or C1-6alkoxy, or X and Y together form a group =O or =NOR<5> where R<5> is H or C1-6alkyl; Z represents O, S or NR<2>, where R<2> is H or C1-6alkyl; W represents a bond or a saturated or unsaturated hydrocarbon chain of 1, 2, 3, 4, 5 or 6 carbon atoms; R<1> represents H or C1-6alkyl. R<3> represents H, C1-6alkyl or C2-6alkenyl; R<4> represents an optionally substituted phenyl group; and R<6> represents a specified amino group or an optionally substituted aromatic or non-aromatic azacyclic or azabicyclic group; and salts and prodrugs are tachykinin receptor antagonists.