| 发明名称 |
Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| 摘要 |
The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically comprise at least one glycoconjugate from a S. pneumoniae serotype not found in PREVNAR®, SYNFLORIX® and/or PREVNAR 13®. The invention also relates to vaccination of human subjects, in particular infants and elderly, against pneumoccocal infections using said novel immunogenic compositions. |
| 申请公布号 |
US9492559(B2) |
申请公布日期 |
2016.11.15 |
| 申请号 |
US201514597488 |
申请日期 |
2015.01.15 |
| 申请人 |
Pfizer Inc. |
发明人 |
Emini Emilio Anthony;Watson Wendy Jo;Prasad Avvari Krishna;Han Mingming;Kim Jin-Hwan;Gu Jianxin;Yang Yu-ying;Kainthan Rajesh Kumar;Cooper David;Pride Michael William;Jansen Kathrin Ute |
| 分类号 |
A61K39/00;A61K39/02;A61K39/09;A61K39/385;A61K47/48 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
Molenda Victoria S. |
| 主权项 |
1. An immunogenic composition comprising a Streptococcus pneumoniae serotype 22F glycoconjugate, wherein the glycoconjugate has a molecular weight of between 1000 kDa and 12,500 kDa and comprises an isolated capsular polysaccharide from S. pneumoniae serotype 22F and a carrier protein, and wherein a ratio (w/w) of the polysaccharide to the carrier protein is between 0.4 and 2. |
| 地址 |
New York NY US |
