| 发明名称 | Wound healing metakaryotic stem cells and methods of use thereof | ||
| 摘要 | The invention provides methods of identifying wound healing metakaryotic stem cells, identifying molecules to modulate proliferation and/or migration of metakaryotic stem cells and molecules to treat wound healing disorders, such as blood vessel wound healing disorders, including restenosis. The invention also provides methods of diagnosing and treating wound healing disorders, such as blood vessel wound healing disorders and also of treating wounds by the use of metakaryotic stem cell transplant(s). | ||
| 申请公布号 | US9499851(B2) | 申请公布日期 | 2016.11.22 |
| 申请号 | US201113879675 | 申请日期 | 2011.10.24 |
| 申请人 | Massachusetts Institute of Technology | 发明人 | Gostjeva Elena V.;Thilly William G. |
| 分类号 | C12Q1/02;G01N33/50;G01N33/68 | 主分类号 | C12Q1/02 |
| 代理机构 | HoustonHogle LLP | 代理人 | HoustonHogle LLP |
| 主权项 | 1. A method for detecting bell-shaped nuclei in metakaryotic stem cells in a subject, the method comprising: a) obtaining a vascular tissue sample from the subject suspected of having neointimal hyperplasia or restenosis; b) partially dissociating the tissue sample by macerating and spreading the tissue sample by a method that substantially preserves the integrity of bell-shaped nuclei of metakaryotic stem cells in the tissue sample, the nuclei having maximum diameters from about 10-50 microns; c) fixing and staining the tissue sample to visualize the bell-shaped nuclei of the metakaryotic stem cells; d) detecting the presence and/or absence of metakaryotic stem cells in the subject tissue sample and in a control tissue sample. | ||
| 地址 | Cambridge MA US | ||