发明名称 |
Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
摘要 |
Provided herein are stereoisomerically pure ester and carbonate analogues of nicotinamide riboside and nicotinamide riboside hydride, and pharmaceutical compositions and uses thereof. The stereoisomerically pure ester and carbonate analogues of nicotinamide riboside and nicotinamide riboside hydride may be used to treat a disease or disorder that would benefit from increased NAD levels including a mitochondrial disease or disorder, insulin resistance, a metabolic syndrome, diabetes, obesity, for increasing insulin sensitivity in a subject, or to treat or prevent a skin condition. The compounds have general formulas (I) or (II) wherein R |
申请公布号 |
AU2015270090(A1) |
申请公布日期 |
2016.12.22 |
申请号 |
AU20150270090 |
申请日期 |
2015.06.05 |
申请人 |
GlaxoSmithKline Intellectual Property (No.2) Limited |
发明人 |
Szczepankiewicz, Bruce;Preugschat, Frank;Koppetsch, Karsten;Perni, Robert B. |
分类号 |
C07H19/048;A61K31/7064;A61P3/10;A61P17/00;A61Q17/00 |
主分类号 |
C07H19/048 |
代理机构 |
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代理人 |
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地址 |
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