Methods for treating denervation-induced muscle atrophy

摘要

The present invention provides methods for the treatment of denervation-induced skeletal muscle atrophy, and generally, denervation-induced skeletal muscle degeneration diseases using agents that decrease the activity of mammalian target of rapamycin and/or the activity of at least one of the Forkhead Box Transcription Factors 1, 3 and 4.

主权项

1. A method of attenuating denervation-induced skeletal muscle atrophy in a mammalian subject, comprising administering to said subject suffering from denervation-induced skeletal muscle atrophy a composition comprising an agent that decreases activity of mammalian target of rapamycin complex 1 in a dosage and dosing regimen effective to attenuate denervation-induced skeletal muscle atrophy in said subject.