VIRUSES AND THEIR USE IN THERAPEUTIC METHODS

摘要

PROBLEM TO BE SOLVED: To provide viral vectors (e.g. herpes viral vectors) and methods of using these vectors to treat disease.

SOLUTION: A herpes virus includes a first mutation that inactivates the γ34.5 neurovirulence locus of the virus and a second mutation that results in early expression of US11, in the absence of an ICP47-inactivating mutation in the BamHIx fragment of the virus. Further, there provided is herpes simplex-1 virus that include sequences encoding a heterologous gene product such as a vaccine antigen or an immunomodulatory protein.

COPYRIGHT: (C)2009,JPO&INPIT