2-amino-2-alkyl-4 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors

摘要

2-amino-2-alkyl-4 heptenoic and heptynoic acid derivatives of formulae (I), (II), (III), (IV), (V) and (VI) and their use in therapy, in particular their use as nitric oxide synthase inhibitors are disclosed, wherein: R1 is selected from the group consisting of hydrogen, halo, and C1-C5 alkyl, wherein the C1-C5 alkyl is optionally substituted by halo or alkoxy, wherein the alkoxy is optionally substituted by one or more halo; R2 is selected from the group consisting of hydrogen, halo, and C1-C5 alkyl, wherein the C1-C5 alkyl is optionally substituted by halo or alkoxy, wherein the alkoxy is optionally substituted by one or more halo; R3 is C1-C5 alkyl which may be optionally substituted by halo or alkoxy, wherein the alkoxy is optionally substituted by one or more halo.