| 摘要 |
<p>Disclosed is a compound useful as a prophylactic or therapeutic agent for a disease induced by abnormal plasma uric acid level or the like. Specifically disclosed is an (aza)indole derivative represented by the general formula (I), a prodrug or salt thereof, or the like, which has a xanthine oxidase inhibitory activity and is useful as a prophylactic or therapeutic agent for a disease induced by abnormal plasma uric acid level. In the formula (I), T represents a nitro, a cyano or the like; the ring J represents an aryl or a heteroaryl; Q represents a carboxy, a 5-tetrazolyl or the like; Y represents H, OH, NH2, a halogen, a nitro,analkyl, an alkoxy or the like; X1, X2 and X3 independently represent CR2 or N; and R1 and R2 independently represent a halogen, a cyano, a haloalkyl, A-D-E-G, -N(-D-E-G)2 or the like [wherein A represents a single bond, O, S or the like; D and G independently represent an alkylene which may be substituted, a cycloalkylene, a heterocycloalkylene, an arylene, a heteroarylene or the like; and E represents a single bond, O, S, COO, SO2 or the like].</p> |
